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The degree of substitution, which indicates how many of the hydroxyl groups in cellulose are replaced by hydroxypropyl and methoxy groups, significantly affects HPMC’s solubility. HPMC with a higher degree of substitution tends to be more soluble in cold water, promoting faster hydration and gelation. As a result, formulators can select the appropriate type of HPMC based on the specific requirements of their applications.
hpmc solubility in cold water
